NovaStem is a procedure that takes cells from your own body and uses them on the skin again. The starting point differs from fillers, which place a material made outside the body.
SVF and PRF, which often appear together, differ in material. First separate whether cells are collected from fat, fibrin is made from blood, or cells are prepared as a hospital program.
3-line summary
1. SVF is a fraction of mixed cells collected from fat, PRF is fibrin made from blood, and NovaStem is Cellinique’s autologous-cell procedure name.
2. SVF, which involves removing fat, and PRF, which is prepared by a blood draw, differ in same-day burden.
3. The three are not received all on the same day; pregnancy, infection, blood disorders, and medications currently taken are disclosed first.
The three procedures differ in material
Comparison does not start from a ranking of effects, but from what is taken and from where. SVF is the name of a cell fraction obtained from fat, and PRF is the name of fibrin obtained from blood. NovaStem is the procedure name given by Cellinique.
| Item | NovaStem | SVF | PRF |
|---|---|---|---|
| Material | A hospital program that uses your own cells | Mixed cells collected from your own fat | Fibrin made from your own blood |
| Collection | Collection site is decided in consultation | Fat harvest from the abdomen, thighs, etc. | Venous blood draw |
| Preparation | Hospital program steps | Separated the same day without culture | Centrifuged without adding a drug |
| What is used | Living cells | A fraction in which several cell types are mixed | Fibrin that contains platelets |
Material from your own body sidesteps immune rejection issues related to another person’s tissue. The possibility of swelling, bruising, and infection from collection and injection remains.
SVF, which involves removing fat
SVF (stromal vascular fraction, Stromal Vascular Fraction) is the cell cluster that remains after mature fat cells are removed from harvested fat. An international society joint statement defines this cluster as a fraction in which vascular cells, immune cells, and stromal cells are mixed. Among the statement’s authors are researchers who disclosed related company consulting roles and patents.
Cells expanded by culture and SVF are kept separate in that statement. The SVF mentioned in aesthetic consultation is usually isolated and used on the same day fat is harvested. Before the skin is injected, the procedure first includes a step of removing fat. Swelling, bruising, and compression care at the harvest site are considered separately from facial injection.
The stem-cell procedure that the international society patient handbook lists as standard is transplantation used for blood and immune diseases. Autologous cell procedures used for skin aesthetics sit outside that list. The name of cells obtained from fat can be confirmed further in the guide to SVF, often called adipose stem cells and the SVF procedure information.
PRF, prepared by a blood draw
PRF (Platelet-Rich Fibrin) is a procedure that spins your own blood to make fibrin containing platelets. An early technical paper wrote that it is prepared without adding a drug to the blood, and its authors include the researcher who first introduced PRF.
It is placed next to similarly named PRP (platelet-rich plasma), but the preparation method differs. A literature review that compared the two around the eyes did not choose one of PRF or PRP, and the reported reactions were temporary redness, swelling, and bruising.
PRF is a blood procedure that uses platelets and fibrin. Bruising and redness at the blood-draw and injection sites are the center of same-day burden. The process can be confirmed in the PRF procedure information and the PRF standalone guide.
When NovaStem is placed next to SVF and PRF
The three names appear together in search because they are placed side by side in consultation as procedures that take material from your own body. NovaStem does not refer to SVF’s fat fraction, nor to PRF’s blood fibrin. According to Cellinique’s information, it is a program that gathers components used for regeneration from your own cells and applies them.
Collection site and processing steps are confirmed in the program documents and the explanation given that day. Mechanism and process are organized separately in the NovaStem procedure information and the NovaStem complete guide.
| Same-day burden | SVF | PRF | NovaStem |
|---|---|---|---|
| Collection | The step of removing fat | Blood draw | Follows the collection method |
| Common reactions | Swelling and bruising at harvest and injection sites | Redness and bruising at blood-draw and injection sites | Reactions at collection and application sites |
| Daily life | Compression and movement of the harvest site are considered first | Redness at the injection site is considered first | Guidance matches the collection method |
When choosing among the three
Ask the following as written before consultation, and the materials will separate.
- □ Whether the material used today is a fat fraction, blood fibrin, or a hospital autologous-cell program
- □ If cells are used, whether there is a culture step that increases cell numbers
- □ Collection site and movements restricted in daily life that day and the next day
- □ Pregnancy and breastfeeding, active infection, blood disorders, anticoagulants and immunosuppressants
- □ Whether the three will proceed on the same day, or the next will be scheduled after seeing recovery from collection
Frequently asked questions
Q1. How burdensome is collection?
SVF includes a step of removing fat, so same-day burden is greater than a blood draw. For PRF, redness and bruising at the blood-draw and injection sites are central. For NovaStem, burden varies with the collection method, so the collection site is confirmed first in the explanation given that day.
Q2. How many sessions?
The next schedule is set according to recovery from collection and skin condition.
Q3. How long does it last?
In a review that collected literature using PRF around the eyes, there was a report that texture change weakened around half a year. Duration for SVF and NovaStem is not grouped under that number and is reviewed separately at follow-up.
Q4. Can they be received together?
Fat harvest and a blood draw are not received together on the same day. After seeing recovery of the collection site, the next material is decided.
Q5. Who should postpone the schedule?
During pregnancy and breastfeeding, active infection, blood disorders, and use of anticoagulants or immunosuppressants, the schedule is reset in consultation. If fat harvest is difficult, it is hard to obtain material for SVF.
Results, duration, and suitability vary with individual skin condition, age, and lifestyle, and the same outcome cannot be guaranteed.
Procedures may cause temporary redness or swelling, and contraindications may apply, so please confirm these during your consultation.
This article is general information and does not replace individual medical care. Please confirm diagnosis and treatment suited to your condition during a consultation.
Sources
- Bourin P et al. (2013), Cytotherapy: Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT) (PMID 23570660)
- Dohan DM et al. (2006), Oral Surg Oral Med Oral Pathol Oral Radiol Endod: Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution (PMID 16504849)
- Sollitto CF et al. (2025), J Cosmet Dermatol: A Systematic Review of Platelet-Rich Plasma Versus Platelet-Rich Fibrin for Periorbital Rejuvenation (PMID 41190633)
- International Society for Stem Cell Research (ISSCR): Patient Handbook on Stem Cell Therapies (February 2024)
Related reading
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