Rejuran Healer is made from sodium polynucleotide (PN), large molecular fragments obtained from fish DNA. Korea's MFDS classifies this product as a medical device used to supplement tissue in the body, namely a biomaterial for tissue restoration. The PharmaResearch Co., Ltd. instructions for use state the authorized indication in Korea as "temporary improvement of facial wrinkles in adults." That is the only sentence written as the authorized indication.
3-line summary
Rejuran Healer, i, and S are grouped under the same authorization; HB and HB plus are separate products. Which instructions for use to check depends on the name you were offered.
Human data that used Rejuran itself come from a 30-person, 12-week study of crow's-feet wrinkles.
Pregnancy, breastfeeding, and minors are contraindications, and it is also not used on sites that have received non-absorbable filler.
Rejuran Healer as written on the authorization
To understand the product accurately, you should not look only at the trade name; check the ingredient name, authorization documents, and intended use together. Authorization is distinguished by item, not by trade name. Therefore, the instructions for use that serve as the basis also differ depending on which product you were offered.
| Product labeling | Applicable authorization documents |
|---|---|
| Rejuran Healer (authorized item name: Rejuran) |
Same authorization documents |
| Rejuran i | Same authorization documents |
| Rejuran S | Same authorization documents |
| Rejuran HB · HB plus | Separate authorization documents for each product |
Studies that tested Rejuran, studies that tested PN
Data that used the product itself in people and data that addressed the ingredient PN carry different weight. The former is a 2020 Korean study. Studies that looked at cells and animals, and analyses that pooled multiple human studies, all took the ingredient PN—not the product—as their subject.
| Level of evidence | What was measured | Scope of interpretation |
|---|---|---|
| Cell and animal experiments | Collagen I·III synthesis increased in a pathway involving macrophages, a type of immune cell, and in animal models collagen density and elasticity improved. | Mechanism of action confirmed in cells and animals |
| Comparative study in 30 people | After following 30 people for up to 12 weeks, the wrinkle improvement rate was 41.38%. Compared with polycaprolactone, a filler of a different ingredient, results showing it was better did not emerge. | Short-term results limited to the crow's-feet area |
| Analysis pooling 9 human studies | 9 studies and 219 people were reviewed, and the possibility of improvement in wrinkles, skin texture, and elasticity was reported. Adverse effects were generally mild and did not last long. | Certainty of the evidence is low or moderate, and higher-quality studies are needed. |
Contraindications, adverse effects, and aftercare
Before the procedure, the physician must adequately explain to the patient what symptoms this product is used for, cases in which it must not be used, and what the adverse effects are. Even before hearing that explanation, you can check the items below against your own situation. If even one applies, you fall under a contraindication as defined by the instructions for use.
- □ Pregnancy or currently breastfeeding
- □ Minors — the authorized indication itself is limited to adults
- □ Skin damaged by inflammation or infection
- □ Allergic disease or autoimmune disease
- □ Sites that have received non-absorbable filler (regardless of when it was injected), or sites that recently received filler
- □ History of hypersensitivity reaction to sodium polynucleotide
- □ Currently taking or receiving anti-inflammatory analgesics (NSAIDs such as ibuprofen), blood-thinning medicines, or immunosuppressants
Even if the last item applies, do not stop or change prescribed medicines on your own; consult the prescribing clinician first.
The injection site may become red and swollen. Itching or pain may accompany this, and these reactions can last about 1 week. The injection site may also feel firm to the touch or change color. Do not apply makeup for 12 hours after the procedure. For 2 weeks afterward, avoid prolonged exposure to sunlight, ultraviolet light, cold, and heat, and avoid environments of prolonged heat such as saunas and jjimjilbang.
Frequently asked questions
Q1. How long do the effects last?
Human studies that used Rejuran itself followed participants for up to 12 weeks. The instructions for use also state that safety and efficacy of long-term use beyond the period established in clinical research have not been confirmed, and they limit the authorized wording to "temporary improvement."
Q2. Who can administer Rejuran?
People who are not physicians cannot use this product. The instructions for use take the view that procedure technique determines treatment success, and they specify that a physician skilled in this procedure must perform it in person. The syringe and needle are single-use, so reusing leftover product or re-sterilizing it for reuse is also prohibited.
Q3. If you were offered Rejuran HB, what should you check?
You need to look at different instructions for use. Both the intended use and the contraindications may differ, so first ask the name of the product you were offered and check the contraindication list in that product's instructions for use.
Q4. What if redness has not settled after 1 week?
You should be examined as soon as possible. The instructions for use specify prompt medical examination if inflammation continues for more than 1 week. Do not wait longer; contact the place where you received the procedure first.
Q5. If you scar easily, should you mention this in advance?
Yes, you should. Safety has not yet been established in people who tend to form thick raised scars or dark residual color when wounds heal. If you have had herpes around the mouth, you should also mention that it can recur after injection so the physician can include this in the assessment.
Results, duration, and suitability vary with individual skin condition, age, and lifestyle, and the same outcome cannot be guaranteed.
Procedures may cause temporary redness or swelling, and contraindications may apply, so please confirm these during your consultation.
This article is general information and does not replace individual medical care. Please confirm diagnosis and treatment suited to your condition during a consultation.
Sources
- PharmaResearch Co., Ltd. Rejuran instructions for use (2024-12 revision)
- Byun KA et al. (2025), Int J Mol Sci: Polynucleotides Enhance Collagen Synthesis via Modulating Phosphoenolpyruvate Carboxykinase 1 in Senescent Macrophages: Experimental Evidence (PMID 40943641)
- Jeong GJ et al. (2020), J Cosmet Dermatol: A randomized, patient/evaluator-blinded, split-face study to compare the efficacy and safety of polycaprolactone and polynucleotide fillers in the correction of crow's feet: The latest biostimulatory dermal filler for crow's feet (PMID 31680395)
- Lampridou S et al. (2025), J Cosmet Dermatol: The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review (PMID 39645667)
Related reading
Treatment information on Rejuran, along with cost, pain, and comparisons with other ingredients, can be read further in the following guides.
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