Re2O is a skin booster that injects human acellular dermal matrix (hADM), made by removing cells from donated human skin. Rather than waiting for the skin to remake collagen on its own, it is closer to filling in an existing tissue scaffold.
3-line summary
1. On one side of the same person's face they injected a mix that included Re2O; on the other side they injected hyaluronic acid only, and compared the two.
2. Measures of density, elasticity, wrinkles, pores, and hydration moved more on the Re2O-mixed side, and observation ran through about five months.
3. That syringe also contained hyaluronic acid, saline, and an anesthetic, and the test article was provided by the manufacturer.
The material Re2O injects
Even products that share the name skin booster differ in what goes into the syringe. What Re2O injects is not living cells, but the collagen and elastin scaffold left after cells are removed from donated dermis. Materials and manufacturing are covered in the Re2O skin booster guide, and why the scaffold weakens is covered in the ECM booster guide.
When discussing results, it is more accurate to look at how the filled-in scaffold appeared on the face than at how strong the stimulus is. The findings below come from that facial comparison.
Measures that changed on the human face
Korean researchers split the faces of adults with uneven cheek texture into left and right sides. One side received a formulation mixing Re2O with hyaluronic acid, saline, and an anesthetic; the other side received a hyaluronic acid skin booster only. The same volume was placed in the mid-dermis, and one of the authors served as an advisor on the manufacturer's product development.
| Measure assessed | Change seen in the left–right comparison |
|---|---|
| Density and volume | Rose more on the Re2O-mixed side |
| Elasticity | The difference versus the other side was larger at an early time point and toward the end of observation |
| Wrinkles | Nasolabial and under-eye wrinkle depth became shallower |
| Pores | From the mid-period onward, the amount of reduction was larger |
| Hydration and barrier | From the mid-period, hydration and water-loss measures were better than on the other side |
| Eye area and cheek line | At the five-month time point, they were measured as higher |
※ The test article was provided by the manufacturer. The findings are a left–right comparison of the mixed formulation as a whole, and values for Re2O used alone were not measured separately.
When, and after how many sessions, did changes appear?
The trial plan called for three sessions at one-month intervals. Skin measurements began at 1 week after injection and continued through about five months.
| Time point | Pattern seen on the face |
|---|---|
| Relatively early | A left–right difference appeared in density, and an elasticity difference was also seen at this time |
| From the mid-period onward | Left–right differences in pore, hydration, and barrier measures became clearer |
| About five months | This is the time point at which measurement ended. Maintenance in the following month was not measured in this trial |
Values after a single session are not covered in this material. Actual session count and interval are planned again according to the area and skin condition. The treatment flow is covered in the Re2O skin booster complete guide.
Reactions after treatment and what to disclose in advance
During the same observation period, the number of reported serious adverse events was 0. The reactions that appeared were temporary redness and mild swelling, and they settled without separate treatment.
The trial formulation contained an anesthetic. You can ask before treatment which anesthesia is used in the actual procedure.
People with the following conditions could not enter that trial: breastfeeding, autoimmune disease, a history of severe allergy, recent facial filler, botulinum toxin, or laser, and recent anticoagulant use. If any of these apply, please mention them before treatment. Common precautions are also set out in the safety information.
How to confirm the changes
To see whether the results align with your own schedule, start by confirming the syringe you would receive today and the number of sessions.
- □ How much hyaluronic acid is mixed into today's syringe besides Re2O
- □ How many sessions at how many weeks' interval, and whether the data is from a single session only
- □ Whether the duration described goes beyond five months, and which formulation that figure is based on
- □ Whether recent facial procedures, breastfeeding, allergies, and medications have already been mentioned
- □ How many days redness and swelling after treatment are expected to last
A side-by-side comparison of procedures that use different materials is covered in Re2O vs Rejuran. Consent items for human-derived materials are in the consultation guide for human tissue-derived materials.
Frequently asked questions
Q1. Does the procedure hurt?
It is an injection procedure, so a sting is present. A pain score was not included in this trial report.
Q2. Is a single session enough?
The trial measured changes on the premise of three sessions at one-month intervals. The actual number of sessions is planned again after reviewing the area and skin texture.
Q3. How long do the results last?
The last time point at which skin-change values were measured is about five months. Maintenance in the following month was not measured in this trial. If a longer period is described, confirm the formulation that figure is based on.
Q4. Can it be combined with other facial procedures?
During the trial period, the condition was not to receive other facial procedures at the same time, such as filler, botulinum toxin, or laser. Actual combination is sequenced after reviewing previous treatment history.
Q5. Who should not receive it?
Conditions that kept people out of the trial were breastfeeding, autoimmune disease, severe allergy, recent facial procedures, and recent anticoagulants. If any of these apply, please mention them before treatment. Active inflammation or infection is also checked at the same visit.
Results, duration, and suitability vary with individual skin condition, age, and lifestyle, and the same outcome cannot be guaranteed.
Procedures may cause temporary redness or swelling, and contraindications may apply, so please confirm these during your consultation.
This article is general information and does not replace individual medical care. Please confirm diagnosis and treatment suited to your condition during a consultation.
Sources
- PMID 41828422 (PMC12985180) — Abstract and full text confirmed. Split-face comparison in 20 people, Re2O+hyaluronic acid+saline+anesthetic mix vs hyaluronic acid, 20 weeks. Density, elasticity, wrinkles, pores, hydration, and related measures moved more in the test group. Serious adverse events 0, temporary erythema and swelling. Limitations: small scale, short term, mixed formulation, manufacturer-provided product, manufacturer advisor among the authors. No retraction or expression of concern (Europe PMC).
- ClinicalTrials.gov NCT07155278 — Registration record confirmed. The same trial as above. Three sessions at one-month intervals; the test group received Re2O+hyaluronic acid. Exclusions: breastfeeding, autoimmunity, severe allergy, recent facial procedures, anticoagulants. Limitation: this is the plan and eligibility criteria, not a results table.
Related reading
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