Rejuran is an injection that places PN (sodium polynucleotide) into the skin. The instructions for use state that it is used to temporarily improve facial wrinkles in adults. Rather than filling a site all at once the way hyaluronic acid does, it is closer to a procedure that looks at skin texture over time.
3-line summary
Rejuran is a PN injection. The authorized wording is temporary improvement of facial wrinkles in adults.
In a left–right comparison of the eye area, changes in roughness and pores lasted longer on the PN side, while the hyaluronic acid side receded after an early sense of volume.
The injection site can become red and swollen, and this can last about 1 week.
What Rejuran does in the skin
The Rejuran syringe contains PN. Product lines and authorized wording continue in the Rejuran Healer guide, and the treatment page continues in the Rejuran treatment information.
PN is large DNA fragments obtained from fish. It is not a procedure that plants genetic information; it is used as an injection placed in the dermis to address skin texture. Experiments that reported increased collagen came from cells and aged animals. The experimental formulation was a product from another company that also mixed in hyaluronic acid and an anesthetic, and among the authors are people affiliated with related companies. What human studies that placed Rejuran by name measured was roughness, pores, elasticity, hydration, and overall scores.
| Item | Rejuran (PN) | Hyaluronic acid hydration injection |
|---|---|---|
| Material injected | PN | Non-cross-linked hyaluronic acid |
| Sites observed on the human face | Eye area and under the eyes | The same sites, opposite side |
| Early on | Elasticity and texture shift later | Volume and hydration fill first |
| Changes that remain afterward | Roughness and pores | Sense of volume recedes |
※ The table shows the direction of a comparison that split the eye area across both sides of the face. Dose and session count are confirmed from that day's product instructions.
Responses that diverged from hyaluronic acid around the eyes
Researchers in Korea placed Rejuran and non-cross-linked hyaluronic acid on the left and right of the same face. They placed it three times at 2-week intervals and followed from the first treatment through week 28. This study was funded by the manufacturer. All participants were women.
Satisfaction scores given by recipients were similar on both sides and declined over time. The overall score seen by investigators was higher on the PN side at week 16. Improvement rates for elasticity and hydration declined on both sides, and at the same week the PN side was higher. The roughness improvement rate rose over time on the PN side and fell on the hyaluronic acid side. Pore volume was also higher on the PN side at weeks 16 and 28. Dermal density did not diverge between the two sides.
There is also a comparison that placed eye-area wrinkles alongside another material through 12 weeks. The wrinkle-score improvement rates of the two materials were similar. Material differences versus Juvelook can be seen in the Rejuran vs Juvelook comparison, and other methods that address collagen in How to increase collagen.
| Check item | What was confirmed |
|---|---|
| Session count used in the study | 3 sessions at 2-week intervals |
| End of observation | 28 weeks after the first treatment |
| Anesthesia | Cream applied for 30 minutes before proceeding |
| Local reactions | Redness, itching, irritation, lumps on the hyaluronic acid side |
| Serious adverse events | Number of reports: 0 |
※ Because the measurement period ran from summer into winter, the elasticity and hydration numbers may have been affected by season.
Reactions after injection, and cases in which it is not used
The instructions for use state that pressure at the injection site can bring redness, swelling, and erythema together with itching or pain, and that these reactions can last about 1 week. Nodules, induration, discoloration, and cases in which change is weak are also written. If inflammation lasts more than 1 week, they instruct prompt medical examination. For 12 hours after injection, makeup is avoided, and for 2 weeks sites of prolonged exposure to strong sunlight, ultraviolet light, cold, and heat such as saunas are avoided. Pain and recovery timing continue in the Rejuran pain and downtime guide.
It is not used during pregnancy or breastfeeding, or in minors. It is also not used on skin with infection or inflammation, at sites that have received non-absorbable filler or recently received filler, or in cases of prior hypersensitivity to sodium polynucleotide. If anti-inflammatory analgesics, anticoagulants, or immunosuppressants are in use, do not stop the medicines on your own; check with the prescribing physician first. The instructions for use state that safety has not yet been established for lip augmentation and for constitutions that form thick scars. At a site that has had herpes, the injection can bring the herpes back. Shared safety information is the treatment safety information.
What to ask as written in the consultation
If you receive the product name, sites, and session count in one line before booking, talk of effects does not mix with the estimate. Cost items can be seen separately in Factors that determine Rejuran cost.
- □ Whether today's product is Healer, i, or HB
- □ Which sites among the eye area and the cheeks will be treated
- □ How many sessions at how many weeks' interval, and when photographs will be compared at the same angle
- □ Whether pregnancy, breastfeeding, medicines, filler, and a herpes history have been disclosed before the appointment
- □ How makeup for 12 hours after injection, and saunas and strong sunlight for 2 weeks, will be avoided
Frequently asked questions
Q1. Does Rejuran hurt?
It is an injection placed into the dermis with a needle. In the eye-area study, numbing cream was applied for 30 minutes before proceeding. Stinging during treatment and bumps immediately afterward come from the needle marks.
Q2. How many sessions?
The eye-area comparison was conducted as 3 sessions at 2-week intervals. The instructions for use do not fix the session count to a single number. It is set to match that day's product instructions and the size of the site.
Q3. How long do the effects last?
In the same study, improvement rates for elasticity and hydration declined over time. Observation ran through 28 weeks after the first treatment. The instructions for use state that only use within the period the study observed is within the confirmed range of safety and efficacy.
Q4. Can it be received together with hyaluronic acid?
There is a comparison that placed them on the left and right of the same face. A schedule for stacking them in the same site on the same day was not set by that study. Sequence is decided after that day's skin response is observed.
Q5. Who should not receive it?
The instructions for use state that it is not used in pregnancy, breastfeeding, or minors, on infected skin, or at sites that have received non-absorbable filler. Sites that have had herpes, and constitutions that form thick scars, are disclosed in advance.
Results, duration, and suitability vary with individual skin condition, age, and lifestyle, and the same outcome cannot be guaranteed.
Procedures may cause temporary redness or swelling, and contraindications may apply, so please confirm these during your consultation.
This article is general information and does not replace individual medical care. Please confirm diagnosis and treatment suited to your condition during a consultation.
Sources
- Eye-area and under-eye PN vs hyaluronic acid comparison (PMID 32248707) — Full text confirmed. Left–right comparison using Rejuran, 3 sessions at 2-week intervals, 28-week observation, roughness, pores, elasticity, hydration. Manufacturer funding. All participants women. Summer→winter measurement. Design limits: single center, 4 dropouts, seasonal confounding.
- Eye-area wrinkle PN vs another material, 12-week comparison (PMID 31680395) — Abstract only confirmed. Wrinkle-score improvement rates similar for the two materials. Product abbreviation RJR. Design limits: abstract scope, 12-week follow-up, small sample.
- PN collagen experiment (PMID 40943641) — Full text confirmed. Salmon-testis PN, collagen density and elasticity in cells and aged animals. Formulation is a product from another company mixing hyaluronic acid and an anesthetic. Among authors, affiliation with related companies and clinics. Design limits: not human-face Rejuran data.
Related reading
Sources
Discuss options for your current needs
We review your current health and prior procedures before explaining appropriate options and their limits.
