For Anyone Exploring Rejuran in Gangnam
Once skin texture, fine lines, or loss of firmness begin to catch your attention, the name "Rejuran" tends to come up. Yet when you actually try to find out what it is — exactly what ingredient it contains, how it works, and how to go about a consultation in Gangnam — clear, well-organized information is surprisingly hard to come by.
This guide covers Rejuran's ingredient, mechanism, procedure process, effects, and safety based on primary sources, along with what to look for when booking a consultation on Dosan-daero in Gangnam. It also includes how Dr. Kim Gun-woo, Medical Director of Cellinique on Dosan-daero, approaches consultations and procedures in practice. For a side-by-side comparison, see the Rejuran vs. Juvelook Comparison Guide.
3-Line Summary
1. Rejuran is a skin booster whose primary ingredient is PN (polynucleotide), purified from salmon DNA. It is approved by Korea's MFDS as a tissue repair biomaterial (Medical Device No. 14-825, 2014, PharmaResearch Co., Ltd.), with a PN concentration of 20 mg/mL.
2. PN works at the level of the dermis, and has been reported to promote collagen synthesis and extracellular matrix (ECM) recovery (via a macrophage-mediated pathway). This is not a "complete in one session" procedure — changes are observed gradually over time.
3. Gangnam's Dosan-daero area has many clinics offering Rejuran. Because efficacy and duration vary significantly between individuals and cannot be guaranteed, we recommend choosing a clinic based on whether the physician personally consults and performs the procedure, and how safety is managed — not price alone.
1. What Is Rejuran? — The Mechanism Behind PN (Polynucleotide)
Rejuran is a skin booster whose primary ingredient is PN (polynucleotide). PN is a high-molecular-weight substance extracted and purified from salmon DNA, and has been reported to have high biocompatibility with the human body. Rather than simply filling in volume, Rejuran supports the skin's own regenerative environment.
Looking at its mechanism more closely: PN is injected into the dermis, where it has been reported to promote collagen synthesis and extracellular matrix (ECM) recovery through micro-stimulation and signal transduction. Recent experimental research describes PN as working primarily through a macrophage-mediated pathway, rather than by directly stimulating fibroblasts — meaning it shifts the immune and regenerative signaling environment of the skin, which in turn drives collagen and ECM recovery.
💡 Fact-check ✓
Source: Korea's MFDS Medical Device Registry · PharmaResearch Co., Ltd. Product Information (IFU)
- Rejuran is approved by Korea's MFDS as Medical Device No. 14-825 (2014, PharmaResearch), classified as a tissue repair biomaterial. Its primary ingredient is sodium polynucleotide (PN), purified from salmon DNA.
- The approved indication is "temporary improvement of facial wrinkles in adults," with a PN concentration of 20 mg/mL.
- Efficacy and duration vary between individuals.
That said, collagen and ECM recovery unfold gradually over time — which means Rejuran is not a procedure where results are complete in one session. It is more realistic to separate expectations between what changes immediately after the procedure and what develops over the following weeks.
💡 Fact-check ✓
Source: Int. J. Mol. Sci. 2025 (PMC12429772)
- Experimental research reports that PN promotes collagen type I and III synthesis and extracellular matrix (ECM) recovery through a macrophage-mediated pathway (M2 polarization · CREB/PCK1 axis).
- The literature describes PN as acting via paracrine signals (IL-10, TGF-β, etc.) secreted by macrophages that stimulate fibroblast collagen synthesis — rather than directly stimulating fibroblasts.
- This is experimental evidence; the degree and nature of individual effects vary.
| Category | Rejuran (PN) | Hydration-Focused Skin Booster |
|---|---|---|
| Primary Action | Collagen/ECM recovery — regenerative support direction | Hydration and surface support |
| Key Ingredient Class | PN (polynucleotide, derived from salmon DNA) | HA (hyaluronic acid)-centered |
| How Changes Appear | Gradual change over time (regenerative direction) | Relatively faster hydration response |
In One Line
Rejuran is a skin booster that uses PN — purified from salmon DNA — to support collagen and ECM recovery. The right approach, suitability, and expected duration are determined during a pre-treatment consultation, as they differ for each person.
2. Rejuran at a Glance
| Item | Overview |
|---|---|
| Primary Ingredient | PN (polynucleotide, derived from salmon DNA) 20 mg/mL |
| MFDS Classification & Approval | Tissue repair biomaterial, Medical Device No. 14-825 (2014, PharmaResearch Co., Ltd.) |
| Approved Indication | Temporary improvement of facial wrinkles in adults |
| Primary Mechanism Direction | Promotes collagen and ECM recovery (as reported) |
| Anesthesia | Topical anesthetic cream (depending on treatment area). Formulations with lidocaine available — confirmed during consultation |
| Downtime | Generally short, but temporary swelling, redness, bruising, and injection marks vary significantly between individuals |
| How Results Are Felt | Gradual change over time; significant individual variation |
| Recommended Sessions & Interval | Determined individually during the pre-treatment consultation |
| Consultation & Procedure | Personally handled by Dr. Kim Gun-woo, Medical Director |
| Cases Requiring Careful Review | Pregnancy/breastfeeding, active infections, anticoagulants/immunosuppressants, autoimmune conditions, ingredient allergies — assessed during consultation |
※ The above is general information. Whether Rejuran is right for you and the specific approach will be determined through a pre-treatment consultation. Results and suitability vary based on individual skin and health conditions.
3. What Are the Different Types of Rejuran?
Rejuran is not a single formulation — it comes in several types depending on the treatment area and objective. That said, the detailed indications and ingredient composition for each type are best confirmed through the product IFU (instructions for use) and Korea's MFDS approved scope.
- Skin texture and fine lines focus — A PN-only formulation typically used for skin texture and firmness management.
- Formulation with lidocaine (e.g., HB Plus series) — Contains PN together with HA and lidocaine, designed with treatment comfort and pain management in mind.
Which type is the right fit depends on your skin condition, treatment area, pain sensitivity, and goals. The specific product selection is made together with the physician during the pre-treatment consultation.
4. What Concerns Prompt People to Consider Rejuran?
Rejuran is not a procedure recommended for everyone. During consultations, the following types of concerns typically come up as reasons people explore it as an option.
If You Have Any of These Concerns
- Concerns about skin surface quality such as skin texture and fine lines
- Noticeable change in firmness compared to before
- Interest in supporting not just hydration but also the skin's regenerative environment
- Thinking about skin management as a longer-term commitment rather than a one-off procedure
Of course, having these concerns does not automatically make Rejuran the answer. It means it is one option to explore during a consultation. Whether it is actually the right fit is determined individually during the pre-treatment assessment.
Cases Where We Proceed with Caution
- Currently pregnant or breastfeeding, or planning to become pregnant
- Active infection or inflammation at the treatment site
- Currently taking anticoagulants, antiplatelet agents, or immunosuppressants
- History of autoimmune conditions
- History of allergy to anesthetic agents (including lidocaine) or the product's ingredients
If any of the above applies to you, please let us know during the pre-treatment consultation. We will confirm whether the procedure is suitable and, if needed, discuss alternative management options.
5. What Does the Rejuran Process Look Like?
At Cellinique, Rejuran is performed in the following sequence. Because injection depth, area design, and recovery management all influence results, we keep the process straightforward and consistent.
- Pre-treatment consultation and skin assessment — Dr. Kim Gun-woo personally reviews your skin condition, texture, firmness, procedure history, current medications, and lifestyle. Whether Rejuran is the right fit, and which formulation is most appropriate, is typically determined at this stage.
- Treatment area and design — The areas where regenerative support would be beneficial are identified, along with whether combination with other procedures is appropriate and in what order.
- Recovery and scheduling review — The timing of the procedure is set based on your downtime availability.
- Procedure — Following topical anesthetic cream, the PN is delivered into the dermis via micro-injection. (Injection depth and volume are tailored to the area and individual condition.)
- Post-procedure care and next session guidance — Post-procedure precautions, recovery checkpoints, and the recommended interval for the next session (if applicable) are explained separately.
💡 A Patient's Note — Some patients seeing Rejuran for the first time say: "I was told in advance that regeneration takes time, so I wasn't anxious when there wasn't a dramatic change right after." That said, recovery and change patterns vary considerably between individuals — please feel free to reach out to Cellinique with any questions during the process.
6. Downtime and Recovery Management
Downtime varies slightly depending on the treatment area and scope. It is generally short, but given that this is an injection-based procedure, temporary swelling, redness, bruising, and injection marks are possible — and recovery varies with individual healing and lifestyle.
Common Reactions Noted Immediately After the Procedure
- Temporary swelling and redness at the treatment site
- Injection marks and mild bruising (when they occur, they typically resolve within a few days)
- Temporary tenderness or a sense of tightness
- Small bumps that may be palpable at certain areas (typically settle with time)
First 24 Hours After the Procedure
- Avoid irritating skincare products, heat, and vigorous cleansing
- Light makeup can be restarted while monitoring the condition of the treatment area
- If you notice any changes in how you feel, please contact Cellinique without hesitation
First Week After the Procedure
- Please avoid saunas, jjimjilbang (Korean sauna), and intense exercise
- Diligent sun protection is important
- Reducing alcohol and avoiding smoking is recommended where possible
The key is that recovery patterns differ between individuals — which makes it important to discuss and plan the recovery timeline and procedure schedule in advance.
7. Safety Standards and Precautions
Rejuran is a genuine medical procedure, and we cannot say it carries zero risk. When combined with other anti-aging procedures in particular, setting realistic expectations and sequencing the treatments thoughtfully matters — which is why Cellinique allocates ample time to consultation, area design, and post-procedure follow-up.
💡 Fact-check ✓
Source: Korea's MFDS Medical Device Registry · PharmaResearch Co., Ltd. Product Information (IFU)
- Rejuran's MFDS-approved indication is "temporary improvement of facial wrinkles in adults." We do not assert effects beyond the approved scope.
- Even when performed appropriately, temporary swelling, redness, bruising, injection marks, and other side effects are possible; in rare cases, nodules, infection, or allergic reactions have been reported.
- The frequency and nature of side effects vary between individuals.
Commonly Reported Reactions
- Temporary swelling, redness, and bruising at the treatment site (most resolve within a few days)
- Rarely, mild tenderness, warmth, or small nodules
- Very rarely, infection, allergic reactions, or persistent nodules
When to Contact Cellinique Immediately
- Severe swelling, warmth, or marked redness at the treatment site
- Fever or chills
- A nodule that remains firm for more than 2 weeks or appears to be growing
- Suspected allergic reaction (hives, difficulty breathing, etc.)
Information to Share Before Your Procedure
- Pregnancy or breastfeeding status (including if you are planning to become pregnant)
- Current medications (particularly anticoagulants, antiplatelet agents, or immunosuppressants)
- History of allergies (including to the anesthetic lidocaine)
- Active infections or autoimmune conditions
- Recent procedures (interval and sequencing adjustments may be needed)
Safety standards that apply across all procedures — side effects, emergency response, contraindications, and infection management — are detailed on the Cellinique Procedure Safety Guide. If you are considering Rejuran, we recommend reviewing it before your appointment.
8. How to Find the Right Rejuran Provider on Dosan-daero in Gangnam
Gangnam — and Dosan-daero in particular — has no shortage of clinics offering Rejuran. The wide range of options is a plus, but rather than being swayed by phrases like "best in Gangnam" or "number one," it is worth knowing what criteria actually matter when choosing.
What to Evaluate Before Comparing Prices
- Does the physician personally consult and perform the procedure? — Because injection depth and area design influence results, consistent medical management matters.
- Safety and sterility management — For an injection-based procedure, confirm that infection control and emergency response protocols are in place.
- Evidence-based consultation — Does the clinic honestly communicate individual variation and the possibility of side effects, without overstating results?
- Post-procedure support — Since results develop gradually over time, the ease of follow-up visits and check-ins is more important than it might seem.
Whether the clinic has a specialist in dermatology is another criterion that often comes up — but this is just one among several reference points. In Korea's aesthetic and regenerative medicine space, outcomes are strongly influenced by the physician's hands-on expertise, experience, and safety management for the specific procedure — independent of specialty board certification. Board certification is a useful reference, but on its own it is not sufficient; verifying the physician's actual understanding of the procedure and safety standards during the consultation is the more practical approach.
How Cellinique Approaches Rejuran
Cellinique is an anti-aging aesthetic clinic on Dosan-daero in Gangnam-gu. For procedures like Rejuran — where injection depth, volume, and area design directly influence outcomes — consistent medical management and deep product understanding are key to stable results.
Dr. Kim Gun-woo personally handles everything from the initial consultation through the procedure and post-procedure follow-up. Cellinique's location on Dosan-daero also makes return visits and follow-up check-ins straightforward — an advantage for a procedure like Rejuran that involves observing gradual change over time. Full details on qualifications and training history are provided during the consultation.
Frequently Asked Questions (FAQ)
Q1. Is Rejuran the same as a filler?
No — Rejuran is different from a conventional filler. Rather than simply filling volume with an external substance, it is a skin booster that uses PN (polynucleotide) to support collagen and ECM recovery. It is approved by Korea's MFDS as a tissue repair biomaterial for the temporary improvement of facial wrinkles in adults. The right approach and suitability are assessed during a pre-treatment consultation.
Q2. When will I start noticing the effects of Rejuran?
Because Rejuran works in the direction of supporting collagen and ECM recovery, changes typically appear gradually over time rather than immediately after the procedure. That said, there is considerable variation depending on skin condition, age, and lifestyle, and identical outcomes cannot be guaranteed for everyone. What you can reasonably expect will be discussed in detail during your pre-treatment consultation.
Q3. How many Rejuran sessions do I need?
The recommended number of sessions and interval depend on skin condition, goals, and the treatment area. It is common to have multiple sessions spaced at regular intervals, but there is no single "correct" number — an individualized plan will be discussed together during the initial consultation. Duration of effect also varies between individuals and cannot be guaranteed.
Q4. Where is the best place to get Rejuran on Dosan-daero in Gangnam?
There are many clinics offering Rejuran on Dosan-daero in Gangnam. Rather than thinking in terms of "best," we recommend evaluating based on whether the physician personally consults and performs the procedure, whether safety and sterility standards are in place, whether individual variation and side effects are communicated honestly, and whether post-procedure support is accessible. At Cellinique (Gangnam, Dosan-daero), Dr. Kim Gun-woo personally handles everything from the initial consultation through follow-up visits.
Q5. What is the difference between Rejuran and Juvelook?
The core ingredients and mechanisms differ. Rejuran uses PN (polynucleotide) to support skin regeneration and recovery, while Juvelook (PDLLA + HA) is understood to work by stimulating collagen production. Because they act differently, combining the two may also be worth exploring in some situations. For a detailed comparison, see the Rejuran vs. Juvelook Comparison Guide.
Q6. What are the side effects and precautions for Rejuran?
As an injection-based procedure, temporary swelling, redness, bruising, and injection marks at the treatment site are possible. Rarely, tenderness or small nodules may occur; very rarely, infection or allergic reactions have been reported. If you are pregnant or breastfeeding, have an active infection, are taking anticoagulants or immunosuppressants, have a history of autoimmune conditions, or have a known allergy to any of the ingredients, please let us know during your pre-treatment consultation. The occurrence and severity of side effects vary between individuals.
Q7. Can I come in just for a consultation?
Of course. Because Rejuran involves decisions around formulation type, treatment area, goals, and sequencing with other procedures, we encourage taking the time to fully understand your options before deciding. Whether or not you proceed with treatment, please feel free to reach out at 02-6203-3434 or via KakaoTalk. (Consultation and procedure fees depend on individual assessment and will be explained during the consultation.)
Closing
Rejuran is not something to pursue simply because it is well known — it is a skin booster that uses PN to support collagen and ECM recovery, explored through a pre-treatment consultation and skin assessment for those for whom it makes sense. What matters is not name recognition or which street in Gangnam you visit, but whether the mechanism is genuinely suited to your skin and goals — and whether you can receive it safely.
At Cellinique (Gangnam, Dosan-daero), Dr. Kim Gun-woo personally handles everything from the initial consultation through the procedure and post-procedure follow-up. If you are interested in Rejuran, we recommend starting with a consultation to talk through your skin condition and care goals. For comparisons with other skin boosters, see the Rejuran vs. Juvelook Comparison Guide; for shared safety standards, see the Cellinique Procedure Safety Guide.
✅ Fact-check Report
The primary medical information in this article has been verified against the following sources.
- Korea's MFDS Medical Device Registry · PharmaResearch Co., Ltd. Product Information (IFU) — Rejuran = sodium polynucleotide (PN, derived from salmon DNA) 20 mg/mL, tissue repair biomaterial, Medical Device No. 14-825 (2014, PharmaResearch Co., Ltd.), approved indication: "temporary improvement of facial wrinkles in adults"
- Int. J. Mol. Sci. 2025 (PMC12429772) — PN mechanism of promoting collagen synthesis and ECM recovery (macrophage-mediated pathway, M2 polarization · CREB/PCK1 axis; paracrine signaling rather than direct fibroblast stimulation)
- Verified items: ingredient (PN, salmon DNA origin) · concentration (20 mg/mL) · MFDS approval number/classification/indication · mechanism · side effects · individual variation disclosed. Degree of effect, duration, and detailed indications by Rejuran type are not asserted as fact due to individual variation and IFU scope limitations.
- Exact ingredient composition and indications by Rejuran type (Healer/HB Plus, etc.) require further confirmation against individual product IFU and MFDS-approved scope.
Medical Disclaimer
This content is intended for general health information purposes only. Individual diagnosis, procedural suitability, and expected outcomes must always be determined through a prior consultation with a qualified medical professional. All medical procedures carry individual variation and the possibility of side effects.
Cellinique — Consultations & Appointments
Yeonseung Building 2F, B1, 228 Dosan-daero, Gangnam-gu, Seoul
Phone: 02-6203-3434
Hours: Monday–Friday 10:00–19:00 / Last Saturday of each month 10:00–16:30
